CNR1 and drug-induced dyskinesia: While stimulating CB1 alone reduces the hyperactivity of the cAMP/PKA pathway, which has been implicated in the development of dyskinesias (Aubert et al., 2005; Martinez et al., 2012), the coactivation of CB1 and TRPV1 generates the opposite effect (Lam et al., 2005), with their participation in the induction of LTP also observed (Cui et al., 2018).