GJA1 and cardiac hypertrophy: Notably, the present data reveal that escitalopram improved the HFFD/STZ-induced cardiac hypertrophy as well as contraction and conduction impairments as evidenced by the normalization of HWI, HR, QTc interval and QRS duration in addition to significant amelioration of α- and β-MHC genes expression and connexin-43 protein expression.