OXR1 has been implicated in a growing list of neurodegenerative diseases such as oxygen-induced retinopathy, diabetic retinopathy, Parkinson’s disease, ischemia-induced neuronal damage, and amyotrophic lateral sclerosis (ALS) (Natoli et al., 2008a; Murray et al., 2013; Finelli et al., 2015; Liu et al., 2015; Puspita et al., 2017; Jiang et al., 2019; Williamson et al., 2019). The gene discussed is OXR1; the disease is amyotrophic lateral sclerosis.