In univariate analyses, insulin clearance was significantly associated with cIMT in participants with newly diagnosed (ßst = − 0.39; p = 0.03) and without diabetes mellitus (ßst = − 0.11; p = 0.03) as well as IFG (ßst = − 0.27; p = 0.01). The gene discussed is INS; the disease is diabetes mellitus.