The expression of some transcription factors, such as Yamanaka factors (OSKM), including Oct3/4, Sox2, c-Myc, and Klf4, reprograms somatic cells to induced pluripotent stem cells (iPSCs).72 This pluripotency reprogramming process is closely related to cancer cell dedifferentiation to cancer stem-like cells (CSCs).73 Similar to pluripotent and stem cells, CSCs have the capacity to self-renew and differentiate into progenitor cells. This evidence concerns the gene POU5F1 and cancer.