KPT-9274 may target to cancer stem cell population, since NAMPT and PAK4 proteins play an important role in EMT activation.309 Interestingly, in B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML) models, the effect of KPT-9274 can be reversed by treating the cells with NAD+ precursors, for example nicotinic acid. The gene discussed is PAK4; the disease is acute myeloid leukemia.