NAMPT and colorectal cancer: In addition, in colorectal cancer and glioblastoma, stable NAMPT-overexpressing cells were substantially more resistant to the apoptosis induced by diverse chemotherapeutic treatments than were their parental counterparts.6–10 In contrast, the cells with NAMPT knocked down, downregulating NAMPT expression, were more sensitive to therapy than were the controls.6–10 NAMPT inhibitors in clinical trials also reduced the growth of cisplatin-treated xenograft tumors in ovarian cells in vivo.