The expression of NAMPT increased tumor cell proliferation, ERK-1/2 and p38 activity levels, the expression levels of metalloproteases, colony formation, and resistance to apoptosis.8,9,46,203 Ectopically expressed NAMPT enhanced neovascularization in vivo and enhanced tube formation by human umbilical vein endothelial cells. The gene discussed is NAMPT; the disease is neoplasm.