SIRT6 and colonic neoplasm: SIRT6 also suppresses the Warburg effect through the inhibition of the pyruvate kinase M2 (PKM2), thereby regulating glucose homeostasis.267,268 SIRT6, on the other hand, maintains genome integrity during tumorigenesis.269 In this regard, high SIRT6 levels have been reported in colon cancer samples, which correlate with worse prognosis.270