CD38 has been described as a negative prognostic marker in chronic lymphocytic leukemia and as a surface marker in multiple myeloma41,298 In addition, CD38 may regulate the sensitivity of pancreatic cancer cells to FK866 treatment.234,299 However, the relationship among NAMPT, NAD+, and CD38 is still poorly understood, and more studies are needed. Here, CD38 is linked to B-cell chronic lymphocytic leukemia.