It has been shown that NAMPT can activate OSKM factors, promoting stemness and dedifferentiation leading to the acquisition of the CSC phenotype in cancer.7,8,10 These phenotypes correlate with the transcriptional signature for stemness, such as high ALDH1A1 and aldehyde dehydrogenase activity, the expression of stem-related genes, and CD133 positivity. This evidence concerns the gene NAMPT and cancer.