NAMPT and colonic neoplasm: eNAMPT correlates with PBEF and visfatin, and it is not surprising to find high eNAMPT levels in different hematopoietic malignancies.10,193,194 iNAMPT localizes to the cytoplasm, nucleus and mitochondria, and NAMPT has also been found to be upregulated in several solid human tumors, including the colon cancer,7 glioma8,9 and breast,195 prostate,196 thyroid,197 and gastric198 carcinomas.