Foxp3+ regulatory T cells (Tregs) are specifically susceptible to NAD+-induced cell death, and systemic administration of NAD+ selectively depletes Tregs, promoting antitumor responses in xenograft tumor mouse models.31 T cells with reduced surface expression of CD38 exhibited higher levels of NAD+ and superior antitumor responses, including enhanced oxidative phosphorylation, higher level of glutaminolysis, and altered mitochondrial dynamics.32 Here, CD38 is linked to neoplasm.