These results suggest that the inhibitory effect seem to be more dependent on NAD+ depletion than on PAK4 blocking.314,315 The dual inhibition of KPT-9274 allows targeting of NAD+ regeneration and PAK4 signaling, which are essential for tumor development and survival, making KPT-9274 an attractive drug candidate for use in chemotherapy.308,316. This evidence concerns the gene PAK4 and neoplasm.