TAS1R2 and obesity due to melanocortin 4 receptor deficiency: This result is interesting when compared to human studies that measured lower expression of PLC-β2, transient receptor potential M5 (TRPM5) and the taste 1 receptor member 2 (TAS1R2) in the fungiform papillae of subjects with obesity [56], and an increase in DNA methylation at these genes from blood samples of people with high BMI [61].