SERPINE1 and colorectal adenocarcinoma: Co-cultures of human colorectal adenocarcinoma cell line CaCo2 and 3T3-L1 adipocytes in the presence of caffeine have shown that caffeine inhibits the secretion of inflammatory cytokines interleukin (IL) IL-8 and plasminogen activator inhibitor-1 (PAI-1) and decreases lipid accumulation in adipocytes, whereas it has no effect on 3T3-L1 cells alone [80].