GNA-related lectins exert their cytotoxic activities on cancer cells mainly by deactivating rat sarcoma-rapidly accelerated fibrosarcoma (Ras–Raf) and PI3K–Akt pathways previously activated by PGE2 autocrine action through the prostaglandin E receptor 1-4 (EP1-4) receptor, inhibiting the proliferation, migration/invasion, and survival of cancer cells. Here, AKT1 is linked to cancer.