AKT1 and cancer: For the sake of brevity, we highlight here some of the salient pathways with potential biological significance in IH, such as: Rap1 signaling pathway (KEGG:04015), p-value 2.21 × 10−20; focal adhesion (KEGG:04510), p-value 5.04 × 10−20; platelet activation (KEGG:04611), p-value, 9.64 × 10−16; phospholipase D signaling pathway (KEGG:04072), p-value 5.58 × 10−14; regulation of actin cytoskeleton (KEGG:04810), p-value 1.86 × 10−12, pathways in cancer (KEGG:05200), 2.08 × 10−12; and PI3K-Akt signaling pathway (KEGG:04151), p-value 3.16 × 10−12 (Table S2A).