CLDN5 and brain ischemia: Naringenin also showed a neuroprotective profile in an animal model of brain ischemia, reducing apoptosis, inflammation, oxidative stress and neurological deficits through the modulation of claudin-5, MMP9, Nrf2, nucleotide oligomerization domain-like receptor 2 (NOD2) and NF-κB [123,125,126].