GPC1 and neoplasm: Additional changes in the tumor cell line were a 4-fold increase in “Chaperone activity” (2.1% in HEK cells versus 8.9% in HCT 116 cells), a slight decrease in “Cell communication”, “Signal transduction”, and “Glypican pathway”, and a 3-fold decrease in the transcriptional repressor CTCF (33.3% in HEK cells versus 11.62% in HCT cells) (Supplementary Table S8A,B), a zinc finger protein which organizes chromatin, and acts as a transcription factor and a tumor suppressor [36].