The LOX family plays additional, non-canonical, roles in organ development [11] and cancer [12,13], as shown for LOX [14], LOXL1 [3], LOXL2 [4], LOXL3 [5], and LOXL4 [15,16], and reviewed in [17,18,19,20,21,22,23,24,25]. The gene discussed is LOXL2; the disease is cancer.