A marked decrease in “Extracellular” location (36.8% in HEK cells versus 21.3% in HCT 116 cells), and a moderate increase in “Cytoplasm” and “Nucleus” were observed for Cellular Component in partners specific to tumor cells, associated with a 2-fold decrease in “signal peptide” (62.5% in HEK293 cells versus 31.5% in HCT 116 cells) (Supplementary Table S8A,B) meaning that the secreted LOX and LOXL protein partners were less abundant in HCT 116 cells. The gene discussed is LOXL1; the disease is neoplasm.