Additionally, another rat study suggested that genistein alleviated NASH through the inhibition of nuclear translocation of NF-κB p65 subunit, and JNK activation leading to the reduction in hepatic inflammatory cytokine levels (i.e., TNF-α, IL-6, TGF-β) and lipid peroxidation markers (i.e., TBARS). Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.