The objectives of the current study were to determine the benefits of genistein supplement on NASH induced by a high-fat, high-fructose (HFHF) diet in the setting of estrogen deficiency and its effects on lipid metabolism, oxidative stress, hepatocyte apoptosis, hepatic PPARγ expression, and adiponectin levels. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.