Moreover, in a NASH model using mice fed with a methionine-choline-deficient (MCD) diet, genistein reduced the levels of oxidative stress markers (i.e., MDA, heme oxygenase), endoplasmic reticulum stress, and the expression of TNF-α, monocyte chemoattractant protein 1 (MCP-1), toll-like receptor 4 (TLR4), and interleukin 1 beta (IL-1β) [33]. This evidence concerns the gene CCL2 and metabolic dysfunction-associated steatohepatitis.