However, we confirmed that the inflammatory cytokines and enzymes used as salivary biomarkers were IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17, IL-32, TNF-α, TNF-β, PGE2, MMP-8, MMP-9, MIP-1α, and TIMP-2, and that IL-1β, TNF-α, MMP-8, and MMP-9 were most commonly used salivary biomarkers to identify the changes after SRP, indicating the potential applicability of saliva for the diagnosis of periodontal disease. The gene discussed is IL1B; the disease is periodontal disorder.