However, we confirmed that the inflammatory cytokines and enzymes used as salivary biomarkers were IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17, IL-32, TNF-α, TNF-β, PGE2, MMP-8, MMP-9, MIP-1α, and TIMP-2, and that IL-1β, TNF-α, MMP-8, and MMP-9 were most commonly used salivary biomarkers to identify the changes after SRP, indicating the potential applicability of saliva for the diagnosis of periodontal disease. This evidence concerns the gene TNF and periodontal disorder.