Here, we could extend the previous findings with the following: biochemical markers of thrombocytosis, namely circulating interleukin-6 and thrombopoietin level of CRC patients were different if the tumor could have been characterized with the occurrence of CgA-positive differentiated cells; both marker appeared to be higher in the CgA− cohort. The gene discussed is THPO; the disease is colorectal carcinoma.