Although neutralizing antibodies against the injected antibody were generated, CD8+ T cells could be efficiently depleted in atherosclerosis-prone Apoe−/− or Ldlr−/− mice by this approach, and the application of an antibody targeting CD8α in Apoe−/− and Ldlr−/− mice [35,36] as well as application of an antibody directed against CD8β in Ldlr−/− mice [36] led to profound reductions in atherosclerotic lesion burden after 6 or 8 weeks of high-fat diet (HFD) feeding. This evidence concerns the gene LDLR and atherosclerosis.