APOE and atherosclerosis: In another study, a pronounced increase in nonatherogenic RORγt+ IL-17-producing CD8+ T cells (Tc17) was noted in advanced atherosclerotic lesions of Apoe−/− mice compared to the spleen [42], which would also be in line with a loss in a proinflammatory and IFN-γ producing cell phenotype in late atherosclerosis.