IFN-γ blockade in high fat diet fed Ldlr−/− mice in part recapitulated the effects of CD8+ T cell depletion on bone marrow monopoiesis during hypercholesterolemia in Ldlr−/− mice [36], suggesting that IFN-γ secretion by CD8+ T cells may at least in part contribute to monopoiesis in the bone marrow and in consequence contribute to Ly6Chi monocytosis during atherogenesis. Here, CD8A is linked to familial hypercholesterolemia.