MKI67 and familial pancreatic carcinoma: In this regard, since we previously demonstrated a decrease in pancreatic cancer proliferation in mice fed with ERSD, as confirmed by a significantly lower expression of Ki67 at the mRNA and protein level [23], we further investigated the activation status of the proliferative PI3K/AKT pathway in tumors from both experimental groups, observing a decreasing trend upon ERSD.