PTEN and familial pancreatic carcinoma: Moreover, when miRNA-target gene pairs were analyzed for the prediction of canonical pathway enrichment by IPA, only PTEN signaling (Fisher’s exact test, adjusted p-value < 0.05) emerged enriched in ERSD miRNA-target genes versus controls fed mice, whereas nine pathways overrepresented among upregulated target genes, included Ephrin Receptor, PIK3/AKT, NF-kB, and IL-8 signaling together with other proinflammatory pathways in pancreatic cancer mice fed with control diet (Figure 2C and Table S3).