Acetylcholinesterase (AChE) inhibitors, like Donepezil, work by decreasing the hydrolysis of Ach and improving memory and cognition [83], while Rivastigmine serves an additional function of blocking not only acetylcholinesterase, but also butyl cholinesterase to increase the chances of managing AD (Figure 3). The gene discussed is ACHE; the disease is Alzheimer disease.