Furthermore, overrepresented pterin synthesis is directly connected with neurotransmitters; Segawa syndrome together with guanosine triphosphate cyclohydrolase deficiency is related to Dopa-responsive dystonia; and 6-pyruvoyltetrahydropterin synthase deficiency is a neurodegenerative disease that, similar to dihydropteridine reductase (DHPR) deficiency, is treated by levodopa. This evidence concerns the gene QDPR and neurodegenerative disease.