An overrepresentation of the metabolic sets associated with Fabry disease [27], pellagra, which, as mentioned above, has a connection with PD, as well as many Dopa-related pathways (Segawa syndrome, pterine biosynthesis, sepiapterin reductase deficiency, guanosine triphosphate cyclohydrolase deficiency, 6-pyruvoyltetrahydropterin synthase deficiency (PTPS), and DHPR-deficiency) was observed. Here, SPR is linked to dihydropteridine reductase deficiency.