TLR4 and neoplasm: In another study, the effects of Chinese propolis (25, 50, and 100 μg/mL) and its major constituent (CAPE, 25 μg/mL) on inflammation-stimulated tumor and the Toll-like receptor 4 (TLR-4) signaling pathway, which plays a crucial role in human breast cancer cell line (MDA-MB-231), were evaluated.