Similarly, it has been reported that oral administration of encapsulated Chinese propolis (at a concentration of 50, 100, and 200 mg/kg/day) for 10 weeks in type 2 diabetic SD rats induced by a high-fat-diet (HFD) and low-dose STZ attenuated the fasting blood glucose and triglycerides, and improved insulin action. This evidence concerns the gene INS and type 2 diabetes mellitus.