IFNB1 and metastatic colorectal cancer: NCT02923466 (Phase 1 Trial of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon Beta (VSV-IFNβ-NIS) Monotherapy and in Combination With Avelumab, in Patients With Refractory Solid Tumors) is a Phase 1 study aimed to evaluate in oncologic patients affected either by metastatic colorectal cancer, NEN or PHEO (estimated enrollment: 114 participants), the maximum tolerated dose (MTD) of VSV-IFNβ-NIS (VV1) in monotherapy and in combination therapy with avelumab (only one defined outcome).