Dystrophic epidermolysis bullosa (DEB) is caused by mutations in the COL7A1 gene, which impair the function of type VII collagen (C7), resulting in blister formation, altered wound-healing processes, and the development of highly aggressive cutaneous squamous cell carcinoma (cSCC) that may lead to metastasis. The gene discussed is COL7A1; the disease is Dystrophic epidermolysis bullosa.