The analysis included the following 23 clinical and biochemical variables recorded at baseline: type of tissue source, tissue collection-liquid biopsy interval time, primary sidedness, resection of primary tumor, total number of tumor lesions (TNL), total tumor burden expressed in mm (SMD), presence of liver metastases, age, sex, albumin, red blood cells, hemoglobin, white blood cells, lymphocytes, neutrophils, platelets, d-dimer, C reactive protein, Charlston comorbidity index, CEA, CA19.9, KPS basal score, smoking habit. This evidence concerns the gene ALB and neoplasm.