AKT1 and rheumatoid arthritis: For instance, 4-(Hydroxymethyl)catechol extracted from fungi in marine sponges was able to modulate the PI3K/Akt/NF-kB pathway, suppressing the Th immune responses and matrix metalloproteinases expression, hence inhibiting the production of inflammatory cytokines in human RA synovial fibroblasts which confirmed its potential anti-RA effect [164].