Integrin (z-score = 2.52, −log(BH-P) = 2.03; genes: 18 upregulated, 4 downregulated) and paxillin (z-score = 2.33, −log(BH-P) = 1.46; genes: 11 upregulated, 1 downregulated) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate ssociation inhibitor (RhoGDI)signaling pathway was predicted to be downregulated in T2D (z-score = −2.14, −log(BH-P) = 2.41; genes: 16 upregulated, 5 downregulated) (Figure 3). This evidence concerns the gene PXN and type 2 diabetes mellitus.