PXN and type 2 diabetes mellitus: According to the IPA, the upregulation of integrin and paxillin signaling pathways, and the downregulation of RhoGDI signaling pathway, in T2D would lead to the activation of cytoskeletal organization, rearrangement and reorganization, cell activation, adhesion, mobility and polarity, lamellipodia and filopodia formation, and actin polymerization and linkage, and the inhibition of actin stabilization (Figure 5).