PARP1 and melanoma: For example, Choi et al. focused on a 100 kb region in chromosome 1 that has been associated to melanoma risk, and observed that the tag SNP rs3219090 was associated to ASE in PARP1, a gene coding for an enzyme that participates in DNA repair, and fine-mapped this effect to preferential binding of RECQL, another DNA repair protein, to a nearby indel [20].