Collectively, upregulation of fibronectin, integrinα5, αSMA, N-cadherin and E-cadherin by LMP1 is associated with EMT and the MMPs expression is associated with degradation of ECM by the recipient cells and therefore aiding in the remodeling the tumor microenvironment [23,29,30,32,73,75]. The gene discussed is FN1; the disease is neoplasm.