CXCL8 and preterm premature rupture of the membranes: Over the past decade, several studies have demonstrated that high levels of inflammatory biomarkers in the AF, such as various pro-inflammatory cytokines (interleukin (IL)-6, IL-8) and matrix metalloproteinase (MMP)-8, are associated with SPTD and its pathological mechanisms in women with PPROM [10–14].