CRP and Mental deterioration: For instance, most studies would only include basic demographics (i.e., age, sex/gender, education) [16, 43, 44], a few others controlled for relevant health behaviors (i.e., alcohol use, smoking) [7, 11] associated with elevated CRP, or medical comorbidities (i.e., cardiovascular disease) [6, 11, 19] that may lie in the casual pathway between inflammation and cognitive decline.