In contrast, RIP-gp mice receiving CpG-matured HIF-1α-Tg BMDCs showed reduced incidence of diabetes compared to mice immunized with wildtype BMDCs (Fig 2B and 2C), while HIF-1α KO CpG-stimulated BMDCs had similar diabetes induction compared to WT (S3 Fig). Here, HIF1A is linked to diabetes mellitus.