This model may have far-ranging implications in that RBS is 1 member of a group of multi-spectrum developmental disorders that include Warsaw Breakage syndrome, Mungan syndrome, Mullegama–Klein–Martinez syndrome, Juberg-Hayward syndrome, epileptic encephalopathy, Baller–Gerold syndrome, and Cornelia de Lange Syndrome [9,10,18–23,48,64,121–123]. The gene discussed is ESCO2; the disease is Cornelia de Lange syndrome.