INS and Alzheimer disease: Furthermore, impaired central insulin signaling manifests similar pathology to that of early AD including neuroinflammation accompanied by deficits in synaptic plasticity and episodic memory (Blazquez et al., 2014; Srodulski et al., 2014), suggesting overlapping mechanisms of central insulin resistance and early AD‐like cognitive impairment (Bedse et al., 2015; Watson & Craft, 2003).