The main findings of the present study are as follows (Figure 7): (i) NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation; (ii) MCC950 suppresses alveolar bone loss with reduced IL‐1β activation and osteoclast differentiation in ligature‐induced periodontitis. The gene discussed is NLRP3; the disease is periodontitis.