H. pylori strains that harbor the cag T4SS have the capacity to translocate the bacterial oncoprotein CagA directly into gastric epithelial cells, and are associated with a higher gastric cancer risk.11 Therefore, we next sought to determine whether Hp0305 and/or Hp1564 were required for CagA delivery to gastric cells. This evidence concerns the gene S100A8 and gastric cancer.