Extra-mammary Paget’s disease (EMPD) is a skin cancer and the possible role of Malassezia-derived AHR ligands in the progression of the disease has been investigated.64 In lesioned tissue, EMPD keratinocytes expression of the AHR target genes CYP1A1 and CCL20 is enhanced. This evidence concerns the gene CYP1A1 and extramammary Paget disease.