CDH1 and hyperplastic polyp: Moreover, the F. nucleatum derived FadA can interact with E-cadherin to promote CRC cells proliferation.74 This may be relevant to serrated lesions, as altered expression and localization of E-cadherins and its associated β-catenin have been described in hyperplastic polyps and serrated adenomas.82 The change in E-cadherin expression may be related to epithelial remodeling and stratification implicated in serrated adenoma formation.