EIF2AK4 and neoplasm: Whereas the endogenous expression of p‐eIF2α is known for its cytoprotective role and its function in cellular adaptation [149], in cancerous circumstances, the phosphorylation of eIF2α by PERK or GCN2 is thought to increase cancer cell survival, tumor growth, and angiogenesis, at least partially through the buffering of translation in order to prevent nutrient depletion [154].