Besides these alterations found in the upstream signaling pathways, the altered expression and activity of numerous eIFs [70] (e.g., eIF4E, eIF4A, eIF2α), as well as the upregulation of ribosomal biogenesis [71] and factors controlling translation in response to stress [72] (e.g., GNC2 and c‐Myc), have all been shown to dysregulate the translation initiation machinery in CRC (Fig. 2). Here, EIF4E is linked to colorectal carcinoma.