Cumulative evidence suggests that AD is a connectome disease (Acosta-Cabronero et al., 2010, Dai and He, 2014, Damoiseaux et al., 2009, Delbeuck et al., 2003, Rose et al., 2000), and abnormal tau spreads via neuronal connections (Clavaguera et al., 2009). Here, MAPT is linked to Alzheimer disease.