Furthermore, tau pathology is related to worse performance in object memory tasks involving the AT system relative to scene memory tasks involving the PM system in cognitive normal older adults, also matching the proposed spread of the disease via neuronal connections, as tau burden was much higher in the AT system compared with the PM system in the early stages of AD (Arnsten et al., 2020; Maass et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.