MAPT and Alzheimer disease: The accumulation of abnormal tau in the MTL and subsequent spread to these cortical memory systems are likely to be particularly relevant for understanding memory deficits in AD, as these systems play dissociable roles in human memory: the AT system is specific for object-related stimuli (i.e., semantic memory) and the PM is specific for remembering scenes (Davachi et al., 2003; Epstein and Kanwisher, 1998; Wang et al., 2020).