However, there have been important recent findings from sporadic AD that suggest that hyperphosphorylated tau proteins that are no longer governed by normal cellular removal mechanisms play a necessary and underappreciated role in AD progression (Musiek and Holtzman, 2015), with some authors even suggesting that this may be the primary step in the disease needed for subsequent AB aggregation (Arnsten et al., 2020; Braak and Del Tredici, 2015). The gene discussed is MAPT; the disease is Alzheimer disease.