COMP and argyrophilic grain disease: In comparison, the module corresponding to more degradation in AGD AF recorded 24 unique proteins, 7 (CILP, CILP2, COL1A1, COMP, HBA1, HBB, PRELP) of which are in strong overlap (χ2 p=2.0 × 10−71) with the 99 proteins higher in outer AF in the spatial proteome (Figure 3I).