We have established a statistically significant decrease of TIMP‐1, TIMP‐2 in CAD patients compared to controls; these inhibitors are decreased in STEMI compared to NSTEMI and stable angina and concerning the number of stenosed vessel and stent treatment, there was no statistical difference between different subgroups but there was a positive correlation between TIMP1 and ‐2. This evidence concerns the gene TIMP2 and coronary artery disorder.