Inversely, TIMP‐1 and TIMP‐2 levels were increased in controls compared to the three CAD subgroups of severity: controls vs stable angina (P < 0.0001), controls vs NSTEMI (P < 0.0001), controls vs STEMI (P < 0.0001), But the level variation TIMPs have no statistically significant between the CAD subgroups. This evidence concerns the gene TIMP2 and coronary artery disorder.