Another author found that patients with CAD had higher MMP‐9 and TIMP‐1 plasma levels but a lower TIMP‐2 level,38 also both increased MMP‐9 and TIMP‐ 1 plasma levels in premature coronary atherosclerosis patients, but with lower MMP‐3 and TIMP‐2 levels.39 This evidence concerns the gene TIMP2 and coronary artery disorder.