In our study, MMP‐9, MMP‐3 blood levels are increased in CAD patients compared to healthy controls, these two biomarkers have a relevant positive correlation between them, also they are higher in the most complicated stage of CAD, that is STEMI compared to NSTEMI and stable angina and their levels change depending on the absence or presence of a stent and the use of bare‐metal or drug elution stent. This evidence concerns the gene MMP3 and coronary artery disorder.