ADM and Sepsis: Interestingly, complete inhibition of ADM signalling by an antibody targeting the C‐terminus of ADM did not improve survival in murine caecal ligation and puncture (CLP) models of sepsis [131], whilst an antibody targeted at the N‐terminus of ADM (HAM1101), which only results in marginal loss of ADM signalling, resulted in a substantial reduction in mortality in the same sepsis model [131].