ADM and Sepsis: ‐High ADM levels likely represent a failing compensatory response, aimed at restoring endothelial barrier functions in sepsis‐ADM‐enhancing therapies have potential beneficial (stabilization of the endothelial barrier) and detrimental (vasodilation) effects in sepsis‐The non‐neutralizing ADM antibody Adrecizumab enhances ADM’s beneficial effects whilst attenuating its detrimental effects [117, 135]