The E2F6 expression was remarkably positively related to tumor purity (r = 0.309, P = 5.08e − 12), B cells (r = 0.23, P = 3.92e − 07), macrophages (r = 0.264, P = 5.74e − 09), CD8+ T cells (r = 0.269, P = 2.40e − 09), neutrophils (r = 0.168, P = 2.33e − 04), and DCs (r = 0.224, P = 7.93e − 07) but no significant correlation with CD4+ T cells in LGG (Figure 7(f)). Here, CD8A is linked to neoplasm.