Thirty-six common targets, including MAPK14, SERPINE1, IL2, NOS2, CASP3, CD40LG, ICAM1, PARP1, IL1A, PTGS2, PRKCA, MAPK1, CXCL11, CAT, EGFR, BCL2, NOS3, BCL2L1, RELA, PPARG, CREB1, PTGS1, SOD1, MAPK8, HSPB1, and CXCL2, of the phlegm-eliminating herbs in the treatment of COVID-19 and phlegm productions were found out in Gene-Cards, wherein the MAPK family and the inflammatory factors were close to the top of the list. This evidence concerns the gene CREB1 and COVID-19.