Interestingly, a study showed in a model of mouse breast cancer, that in response to CCL2 secretion from tumor cells, stromal macrophages were recruited, became intra-epithelial macrophages and induced Wnt-1 production to dismantle E-cadherin junctions, thus promoting early cancer cells dissemination (Linde et al., 2018). The gene discussed is CDH1; the disease is cancer.