For example, a monoclonal antibody raised against Kv10.1 dose-dependently inhibited Kv10.1 currents in neuroblastoma cells, decreased the proliferation of different human cancer cell lines and reduced tumor growth in xenograft models of breast and pancreatic cancer, notably, without acting on Kv10.2 or Kv11.1 (Gomez-Varela et al., 2007). This evidence concerns the gene KCNH1 and familial pancreatic carcinoma.