On the other hand, a more recent work showed that silencing Kv1.5 expression in osteosarcoma cells not only reduces proliferation by blocking the cell cycle at G0/G1 phase, as expected, but also enhances apoptosis through upregulation of Bax and caspase-3 and downregulation of anti-apoptotic Bcl-2 and Bik (Wu et al., 2015). The gene discussed is KCNA5; the disease is osteosarcoma.