TXNDC5 and squamous cell carcinoma: Recent results revealed that in esophaegal squamous cell carcinoma, Kv11.1 stimulates Phosphatidylinositol 3-Kinase (PI3K)/Akt, which leads to upregulation of thioredoxin domain-containing protein 5 (TXNDC5), thus increasing proliferation, inhibiting apoptosis and favoring epithelial-to-mesenchymal transition.