However, expression of Kv1.5 shows an inversed correlation with malignancy in some gliomas and non-Hodgkin’s lymphomas (Comes et al., 2013, 2015), while its high expression, along with that of Kv1.3, correlates with leiomyosarcoma proliferation and aggressiveness (Bielanska et al., 2012). This evidence concerns the gene KCNA3 and central nervous system cancer.