Furthermore, Astemizole increased the anti-proliferative effects of calcitriol on breast cancer both in vitro and in vivo by acting also on Kv10.1 (García-Quiroz et al., 2012, 2014) and increased the sensitivity of lung cancer cell lines to the EGFR inhibitor Gefitinib possibly by acting on both Kv10.1 subcellular localization and expression (de Guadalupe Chávez-López et al., 2017). This evidence concerns the gene KCNH1 and breast carcinoma.