Additionally, the small-molecule inhibitors of Kv2.1 vindoline, SP6616 and ETA were shown to improve β-cell dysfunction and survival and ameliorate hyperglycemia in vivo, suggesting that Kv2.1 inhibition may be exploited in anti-diabetic therapies (Yao et al., 2013; Zhou et al., 2016, 2018). This evidence concerns the gene KCNB1 and Hyperglycemia.