INS and Alzheimer disease: Additionally, levels of IGF1 receptor as well as insulin are dysregulated in AD animal models in human disease tissue, including in astrocytes (Crews et al., 1992; Connor et al., 1997; Frölich et al., 1999; Jafferali et al., 2000; Steen et al., 2005; Moloney et al., 2010; Gupta et al., 2018).