CDH2 and heart failure: In this particular instance, inhibiting the beta2 adrenergic receptor protects N-cadherin adhesion complexes from degradation (Guo et al., 2010), whereas the loss of p110γ function, the catalytic subunit of PI3Kγ, leads to heart failure by the deterioration of N-cadherin and an increase in cAMP levels (Patel et al., 2018).