- PI3Kγ is involved in Neu-1 signaling which governs atherosclerosis development (Gayral et al., 2014) - Genetic and chemical inhibition of PI3Kγ reduces atherosclerosis in vivo (Fougerat et al., 2008) - PI3Kγ directly interacts with GPCR kinase-2 which is observed in cardiac failure (Ghigo and Li, 2015). The gene discussed is NEU1; the disease is atherosclerosis.