TGFB3 and cleft palate: Recently, the responsible genes, such as irf6, tgfβ3, smad5 and faf1, causing cleft palate have been identified, and disruption of these genes is phenocopied in the zebrafish model, validating the genetic relevance of cleft palate in zebrafish to mammalian cleft palate (Cheah et al., 2010; Ghassibe-Sabbagh et al., 2011; Swartz et al., 2011; Dougherty et al., 2013).