Importantly, small molecule enhancement of GCase activity (8 days, compound NCGC00188758) could also reduce aSyn in SNCA- and ATP13A2/PARK9-PD iPSC-derived DAergic long-term cultured neurons (>90 days), which also showed reduced GCase activity (Mazzulli et al., 2016b). Here, ATP13A2 is linked to Parkinson disease.