Generally, GCase deficiency is associated with higher intracellular aSyn levels, in neuronal models and iPSC-derived DAergic neurons from Gaucher’s disease and GBA1-PD patients (Mazzulli et al., 2011; Schondorf et al., 2014; Aflaki et al., 2016; Kim et al., 2018; Burbulla et al., 2019). The gene discussed is GBA1; the disease is Parkinson disease.