Interestingly, SVE coordinates the replenishment of synaptic vesicles following neurotransmission and has emerged as a pathway of PD vulnerability, with SYNJ1 (synaptojanin 1) and DNAJC6 (auxilin) implicated as causal (Blauwendraat et al., 2020) or SH3GL2 (endophilin A1) as risk factor in PD (Nalls et al., 2019; Nguyen et al., 2019). The gene discussed is SYNJ1; the disease is Parkinson disease.