Interestingly, all familial PD SNCA mutations are localized in the N-terminal region of aSyn (A30P, A53E/T, E46K, G51D, and H50Q) (Polymeropoulos et al., 1997; Kruger et al., 1998; Zarranz et al., 2004; Appel-Cresswell et al., 2013; Lesage et al., 2013; Proukakis et al., 2013; Pasanen et al., 2014), and with the exception of G51D and A53E potentiate aSyn oligomerization and/or fibrillization in vitro, but exhibit differential propensity of forming inclusions within cells (Conway et al., 2000; Fares et al., 2014; Lazaro et al., 2014, Lázaro et al., 2016). The gene discussed is SNCA; the disease is Parkinson disease.