The diagnosis of cirrhosis was based on the clinical and laboratory signs of hepatocellular failure and portal hypertension such as stellar angioma, encephalopathy, low serum albumin level, prolonged prothrombin time, ascites, jaundice, esophageal or gastric varices, and irregular hepatic echogenicity of the liver in abdominal US. The gene discussed is ALB; the disease is Varicose veins.