TLR3 and mucocutaneous leishmaniasis: Of note, this viral culprit within Leishmania was found to exacerbate the development of mucocutaneous leishmaniasis due to its capacity to trigger a strong TLR3/TLR7-dependent inflammatory response, which directly correlates with an enhancement in Leishmania metastatic behavior that is characteristic of mucocutaneous leishmaniasis (Ives et al., 2011).